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Prospective study of the association between fasting glucose concentrations and liver cirrhosis risk / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 381-385, 2012.
Article in Chinese | WPRIM | ID: wpr-261997
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between concentration levels of fasting serum glucose and liver cirrhosis.</p><p><b>METHODS</b>A nested case-control study was carried out based on the sample cohort from the Nutrition Intervention Trials previously conducted in one country in Henan province. Using an automatic biochemical analysis system and enzyme-linked immunoassay, baseline serum samples from 310 liver cirrhosis patients and 620 healthy controls were tested for fasting glucose concentration, hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc), and hepatitis C virus antibody (anti-HCV). Baseline demographic information was collected by questionnaire. The serum glucose values were divided into quintiles and applied to a logistic regression model to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).</p><p><b>RESULTS</b>The mean fasting blood glucose level was significantly higher in cases (4.5+/-1.8 mmol/L) than in controls (4.2+/-2.1 mmol/L) (t=-2.414, P=0.016). The individuals in the highest quintile had a significantly higher risk of disease than those in the lowest quintile [OR=1.672 (1.080, 2.588)]. Moreover, increase in glucose level was accompanied by increased risk, and the relation showed statistically significant linearity (P=0.002). The statistical significance of risk remained after adjustment for potential confounders, including sex, age, HBsAg, anti-HBc, and residence running water status [OR=1.96 (1.216, 3.157), P=0.001].</p><p><b>CONCLUSION</b>Elevated serum fasting glucose concentration was an independent risk factor of cirrhosis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Blood Glucose / Female / Humans / Male / Case-Control Studies / China / Epidemiology / Prospective Studies / Risk Factors Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Hepatology Year: 2012 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Blood Glucose / Female / Humans / Male / Case-Control Studies / China / Epidemiology / Prospective Studies / Risk Factors Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Hepatology Year: 2012 Type: Article