Relaxation mechanism of smooth muscle cells and its relationship with penile erection

Hu ZHAO; Rui JIANG

Relaxation mechanism of smooth muscle cells and its relationship with penile erection / 中华男科学杂志

Hu ZHAO; Rui JIANG.

National Journal of Andrology ; (12): 838-842, 2016.

Article in Zh | WPRIM | ID: wpr-262284

Responsible library: WPRO

ABSTRACT

ABSTRACT

The contractile and diastolic function of smooth muscle cells (SMCs) is closely related to penile erection and erectile dysfunction (ED). In addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), sulfur dioxide (SO2), estrogen receptor (ER), P2Y receptor, perivascular tissue (PVT), and calcium activated potassium channel (Kca) are found to be involved in the relaxation of SMCs. This review updates the mechanisms of the relaxation of SMCs and its relationship with ED.

Subject(s)

Humans; Male; Carbon Monoxide; Physiology; Erectile Dysfunction; Hydrogen Sulfide; Metabolism; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Physiology; Nitric Oxide; Physiology; Penile Erection; Physiology; Potassium Channels, Calcium-Activated; Physiology; Receptors, Estrogen; Physiology; Receptors, Purinergic P2Y; Physiology; Sulfur Dioxide; Metabolism

Key words

P2Y receptor; calcium activated potassium channel; erectile dysfunction; perivascular tissue; relaxation; estrogen receptor; smooth muscle cell; sulfur dioxide

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Full text: 1 Index: WPRIM Main subject: Physiology / Sulfur Dioxide / Penile Erection / Carbon Monoxide / Receptors, Estrogen / Potassium Channels, Calcium-Activated / Myocytes, Smooth Muscle / Receptors, Purinergic P2Y / Hydrogen Sulfide / Erectile Dysfunction Limits: Humans / Male Language: Zh Journal: National Journal of Andrology Year: 2016 Type: Article

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