Ubiquitin-proteasome system and sperm DNA repair: An update / 中华男科学杂志
National Journal of Andrology
;
(12): 834-837, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-262285
ABSTRACT
The ubiquitin-proteasome system (UPS) is a proteasome system widely present in the human body, which is composed of ubiquitin (Ub), ubiquitin activating enzymes (E1), ubiquitin conjugating enzymes (E2), ubiquitin protein ligases (E3), 26S proteasome, and deubiquitinating enzymes (DUBs) and involved in cell cycle regulation, immune response, signal transduction, DNA repair as well as protein degradation. Sperm DNA is vulnerable to interference or damage in the progression of chromosome association and homologous recombination. Recent studies show that UPS participates in DNA repair in spermatogenesis by modulating DNA repair enzymes via ubiquitination, assisting in the identification of DNA damage sites, raising damage repair-related proteins, initiating the DNA repair pathway, maintaining chromosome stability, and ensuring the normal process of spermatogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Spermatogenesis
/
Spermatozoa
/
DNA Damage
/
Signal Transduction
/
Cell Cycle Proteins
/
Ubiquitin
/
Ubiquitin-Conjugating Enzymes
/
Ubiquitin-Protein Ligases
/
Proteasome Endopeptidase Complex
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2016
Type:
Article
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