Oral-appliance combined with tadalafil for erectile dysfunction induced by severe obstructive sleep apneahypopnea syndrome / 中华男科学杂志
National Journal of Andrology
;
(12): 792-796, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-262293
ABSTRACT
<p><b>Objective</b>To evaluate the effect of the oral-appliance combined with tadalafil in the treatment of erectile dysfunction (ED) induced by severe obstructive sleep apnea-hypopnea syndrome (OSAHS).</p><p><b>METHODS</b>We equally randomized 90 patients with severe OSAHS-induced ED to groups A, B, and C to be treated with the oral-appliance, tadalafil (10 mg daily qd), and oral-appliance plus tadalafil, respectively, all for 3 months. Then we compared the therapeutic effects among the three groups of patients using the IIEF-5 questionnaire, Sexual Encounter Profile (SEP) diaries, and the intercourse satisfaction rate of the patients' partners.</p><p><b>RESULTS</b>Totally 87 of the patients accomplished the treatment, 29 in group A, 30 in B, and 28 in C. After treatment, group C, as compared with A and B, showed significant increases in the IIEF-5 score (4.18±1.19 vs 2.66±1.63 and 2.77±1.74, P=0.009 and P=0.026), the success rate of penile intromission (SEP2) (85.7% vs 58.6% and 53.3%, P=0.023 and P=0.008), and the success rate of intercourse (SEP3) (64.3%% vs 37.9% and 33.3%, P=0.047 and P=0.018). The overall satisfaction of the female partners was remarkably higher in groups A and C than in B (P=0.027 and P=0.007).</p><p><b>CONCLUSIONS</b>Oral-appliance combined with tadalafil can improve erectile function in patients with severe OSAHS-induced ED, with a better efficacy than either of them used alone.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Orthodontic Appliances
/
Personal Satisfaction
/
Psychology
/
Therapeutics
/
Vasodilator Agents
/
Penile Erection
/
Sexual Partners
/
Surveys and Questionnaires
/
Treatment Outcome
/
Coitus
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2016
Type:
Article
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