CYP1A1 rs4646422 gene polymorphisms not correlated with male infertility in Chinese Han population / 中华男科学杂志
National Journal of Andrology
; (12): 420-424, 2016.
Article
in Zh
| WPRIM
| ID: wpr-262335
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To determine the correlation of the CYP1A1 (rs4646422) gene polymorphisms with male infertility in the Chinese Han population.</p><p><b>METHODS</b>Using the Mass ARRAY iPLEX GOLD technique, we conducted a case-control study on theCYPlA1 (rs4646422) gene polymorphisms in 636 infertile males aged 21-49 years (case group) and 442 normal healthy men aged 23-47 years (control group) of the Chinese Han population. We analyzed the genotypes and allele frequencies in the two groups ofsubjects with the SPSS 20.0 software.</p><p><b>RESULTS</b>Compared with the wild homozygous genotype GG, the heterozygous genotype AG (OR = 1.06, 95% CI 0.81-1.38) and homozygous genotype AA (OR = 1.11, 95% CI 0.56-2.21) showed no correlation with male infertility, nor did the mutant allele A (OR = 1.06, 95% CI 0.85-1.32) in comparison with the wild allele G.</p><p><b>CONCLUSION</b>The CYP1A1 (rs4646422) gene polymorphisms might not be correlated with male infertility in the Chinese Han population.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Case-Control Studies
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China
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Cytochrome P-450 CYP1A1
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Alleles
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Gene Frequency
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Genetics
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Genotype
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Homozygote
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Infertility, Male
Type of study:
Observational_studies
Limits:
Adult
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Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
National Journal of Andrology
Year:
2016
Type:
Article