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Double Contrast Media enhanced MRI with Ferumoxides-Gadolinium on Hepatocellular Carcinoma
Journal of the Korean Radiological Society ; : 433-436, 2004.
Article in Korean | WPRIM | ID: wpr-26258
ABSTRACT

PURPOSE:

To evaluate the effects of Ferumoxides on Gadolinium (Gd) enhanced dynamic liver magnetic resonance imaging (MRI) in cirrhotic patients and also for the diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND

METHODS:

29 patients with liver cirrhosis were examined at 1.5T. 12 patients had HCC. The imaging protocol included GE T1 in and opposed phases, and a breath-hold TSE T2 before and 30-60 min following 0.05 ml/kg Ferumoxides. Four dynamic in-phase GE series were also acquired after an injection of 20 ml of Gd at 2 ml/sec. SNR and CNR were calculated for liver lesion relative to the muscle and background liver respectively. Statistical analysis was performed using the paired t-test.

RESULTS:

The SNR of the liver decreased by 8.6+/-1.20 (p<0.001) after Ferumoxides injection. At the peak of the Gd effect, the liver increased by 6.09+/-1.15 relative to the post Ferumoxides, but it was not significantly different from the pre-Ferumoxides study (p<0.01). Although there was no significant change in post Ferumoxides SNR of HCC, CNR of HCC relative to the liver increased by 7.54+/-1.61 (p<0.05). After the Gd injection, CNR of HCC increased by 15.6+/-3.87 (p<0.05).

CONCLUSION:

The administration of Ferumoxides made HCC CNR increase, and it canceled the effect of Gd enhancement of the cirrhotic liver. The combination of Ferumoxides and Gd makes HCC CNR increase.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Magnetic Resonance Imaging / Carcinoma, Hepatocellular / Contrast Media / Diagnosis / Gadolinium / Liver / Liver Cirrhosis Type of study: Diagnostic study / Practice guideline Limits: Humans Language: Korean Journal: Journal of the Korean Radiological Society Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Magnetic Resonance Imaging / Carcinoma, Hepatocellular / Contrast Media / Diagnosis / Gadolinium / Liver / Liver Cirrhosis Type of study: Diagnostic study / Practice guideline Limits: Humans Language: Korean Journal: Journal of the Korean Radiological Society Year: 2004 Type: Article