Asparagine synthetase activity in pediatric acute lymphoblastic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 272-274, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-262719
ABSTRACT
<p><b>OBJECTIVE</b>To study the cellular activity of asparagine synthetase in different types of childhood acute lymphoblastic leukemia (ALL).</p><p><b>METHODS</b>The cellular activity of asparagine synthetase was detected by HPLC-FLD and Protein measurement in 28 ALL children (7 cases of T-ALL and 21 cases of B-lymphoid lineage ALL) before chemotherapy.</p><p><b>RESULTS</b>The asparagines synthetase activity levels in T-ALL children were significantly higher than those of the B-lymphoid lineage ALL patients, with the median activity level of 9.3 nM Asn/mg protein/hr vs 5.2 nM Asn/mg protein/hr (P < 0.05). The distribution of the asparagine synthetase activity demonstrated a polymorphism in either T-ALL or B-lymphoid lineage ALL patients.</p><p><b>CONCLUSIONS</b>The cellular activity of asparagines synthetase in ALL patients is presented with a polymorphism distribution. The asparagines synthetase activity levels in T-ALL are significantly higher than in B-lymphoid lineage ALL.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asparaginase
/
Aspartate-Ammonia Ligase
/
RNA, Messenger
/
Oncogene Proteins, Fusion
/
Therapeutic Uses
/
Drug Therapy
/
Core Binding Factor Alpha 2 Subunit
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Genetics
/
Metabolism
Limits:
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS