Your browser doesn't support javascript.
loading
Changes of serum and cerebrospinal fluid insulin-like growth factor-II levels in neonates with hypoxic-ischemic encephalopathy / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 187-190, 2006.
Article in Chinese | WPRIM | ID: wpr-262748
ABSTRACT
<p><b>OBJECTIVE</b>Many studies have demonstrated that low levels of insulin-like growth factor-I (IGF-I) may be associated with the hypoxic-ischemic brain damage (HIBD) and that IGF-I has a neuroprotective effect. The role of IGF-II, a structurally and functionally homologous polypeptide with IGF-I, is unclear in HIBD. This study was designed to observe the changes of serum and cerebrospinal fluid (CSF) IGF-II levels in neonates with hypoxic-ischemic encephalopathy (HIE) and to investigate its effects on HIE.</p><p><b>METHODS</b>Serum and CSF IGF-II levels in 41 neonates with HIE were measured by radioimmunoassay in the acute phase (postnatal age 12-24 hrs) and the convalescence phase (postnatal age 10-12 days). The 41 HIE neonates included 10 cases of mild, 12 moderate, and 19 severe HIE. Serum samples of 10 normal neonates were used as controls.</p><p><b>RESULTS</b>In the acute phase, serum IGF-II levels in the Mild HIE group (203.28 +/- 40.09 ng/mL) and the Moderate HIE group (192.33 +/- 39.66 ng/mL) were not significantly reduced, but were obviously reduced in the Severe HIE group (116.72 +/- 39.50 ng/mL) compared with normal controls (229.38 +/- 43.39 ng/mL) (P<0.01). During the convalescence phase, serum IGF-II levels in the Mild HIE group (285.53 +/- 49.44 ng/mL) and in the Moderate HIE group (278.69 +/- 51.34 ng/mL) increased significantly (P < 0.01); CSF IGF-II levels increased in the Mild HIE group from 27.23 +/- 7.82 ng/mL (acute phase) to 81.58 +/- 9.77 ng/mL (convalescence phase) (P < 0.01) and also increased in the Moderate HIE group from 23.43 +/- 7.79 ng/mL (acute phase) to 78.48 +/- 10.44 ng/mL (convalescence phase) (P < 0.01). The patients from the severe HIE group whose neurological symptoms or signs were improved in the convalescence showed higher serum and CSF IGF-II levels than in the acute phase (254.08 +/- 48.50 ng/mL vs 122.21 +/- 46.26 ng/mL; 69.42 +/- 10.20 ng/mL vs 15.05 +/- 7.03 ng/mL; P < 0.01). A positive correlation was found between the serum and CSF IGF-II levels in the HIE group (r=0.69, P < 0.01).</p><p><b>CONCLUSIONS</b>IGF-II levels in serum and CSF are associated with the pathogenesis and the prognosis of neonatal HIE.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Insulin-Like Growth Factor II / Cerebrospinal Fluid / Hypoxia-Ischemia, Brain / Metabolism Type of study: Prognostic study Limits: Female / Humans / Male / Infant, Newborn Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2006 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Insulin-Like Growth Factor II / Cerebrospinal Fluid / Hypoxia-Ischemia, Brain / Metabolism Type of study: Prognostic study Limits: Female / Humans / Male / Infant, Newborn Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2006 Type: Article