Mean values of brain natriuretic peptide in 190 healthy children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 177-180, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-262751
ABSTRACT
<p><b>OBJECTIVE</b>Overseas research has shown the value of brain natriuretic peptide (BNP) in the diagnosis and treatment of heart failure in children. However, a reference range of BNP values is lacking, limiting its clinical application. This study was designed to determine a reference range for children aged 1 to 16 years.</p><p><b>METHODS</b>Plasma BNP (BNP32, NT-proBNP) concentrations were measured in 190 healthy children (95 boys and 95 girls) using an enzyme immunoassay. Their age ranged from 1 to 16 years (mean=10.6 +/- 4.2 years).</p><p><b>RESULTS</b>The mean plasma concentration of BNP32 in 190 children was 51.89 +/- 48.36 pg/mL, with the 10th and the 90th percentile rank of 27.00 pg/mL and 75.00 pg/mL respectively. The mean plasma concentration of BNP32 in girls was 60.33 +/- 62.91 pg/mL, and 44.22 +/- 27.14 pg/mL in boys, but no statistical differences were found. The mean plasma concentration of NT-proBNP in 190 children was 246.04 +/- 67.27 fmol/mL. The girls had slightly higher plasma NT-proBNP levels than the boys, but there were no statistical differences between them. Neither plasma BNP32 concentration nor NT-proBNP concentration was related to age.</p><p><b>CONCLUSIONS</b>This study first reported a reference range of BNP values for healthy Chinese children aged 1-16 years. Both age and gender are not related to BNP values.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptide Fragments
/
Reference Values
/
Blood
/
Sex Factors
/
Natriuretic Peptide, Brain
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS