N-ras and fms gene mutation in idiopathic thrombocytopenic purpura and myelodysplasia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 158-160, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-262915
ABSTRACT
<p><b>OBJECTIVE</b>To explore the pathogenesis of idiopathic thrombocytopenic purpura (ITP) and improve the differential diagnosis from myelodysplastic syndromes (MDS).</p><p><b>METHODS</b>Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) was performed to detect the point mutation of codon 12,13 in N-ras gene and codon 301, 969 in fms gene in adult and aged ITP and MDS patients.</p><p><b>RESULTS</b>In 25 ITP patients, N-ras mutation and fms mutation were detected in one each (4%). Mutations were found in 3 of 8 MDS patients two (25%) with N-ras mutation and one (12.5%) with fms mutation.</p><p><b>CONCLUSIONS</b>Patients with N-ras or fms gene mutation diagnosed as MDS rather than ITP.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Myelodysplastic Syndromes
/
Polymerase Chain Reaction
/
Genes, fms
/
Genes, ras
/
Purpura, Thrombocytopenic, Idiopathic
/
Point Mutation
/
Polymorphism, Single-Stranded Conformational
/
Genetics
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS