Preparation and prescription of enteric coated pellets of Panax notoginseng saponins pellets / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1359-1363, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-263012
ABSTRACT
<p><b>OBJECTIVE</b>To prepare enteric coated pellets containing panax notoginseng saponins.</p><p><b>METHOD</b>Panax notoginseng saponins loaded pellets were prepared by Extrusion-Spheronization method, and coated by Eudragit L30D-55 using Glatt fluid bed with the bottom spray process, central composite design was used to optimize the coating prescription.</p><p><b>RESULT</b>The drug release of enteric coated pellets of panax notoginseng saponins pellets would be lower than 5% in 2 h in simulated gastric fluid, but reach above 85% in 3 h in simulated human gastroenteric environment.</p><p><b>CONCLUSION</b>The enteric coated pellets of panax notoginseng saponins have good acid residence to avoid panax notoginseng saponins from degrading in gastric acid.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Saponins
/
Tablets, Enteric-Coated
/
Pharmacokinetics
/
Chemistry
/
Chemistry, Pharmaceutical
/
Gastrointestinal Tract
/
Drug Stability
/
Panax notoginseng
/
Gastric Acid
/
Methods
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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