Study on dissolution in vitro of Zhike Pingchuan sustained-release tablets / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To establish a method to evaluate the in vitro release of Zhike Pingchuan sustained-release tablets.</p><p><b>METHOD</b>The ephedrine, pseudoephedrine, scopolamine were chosen as marker components components, and the chromatographic conditions were chosen according to the separation of baseline and theoretical plate number for determining the marker in vitro release of Zhike Pingchuan sustained-release tablets; through the dissolution curves of the three active components, the release behavior was judged as well-balanced release or not.</p><p><b>RESULT</b>Compared with conventional tablets, the Zhike Pingchuan sustained-release tablets had a well-balanced behavior in 10 h.</p><p><b>CONCLUSION</b>The maker components of Zhike Pingchuan sustained-release tablets and two chromatographic conditions, which were used to determine the dissolution of the sustained-release tablets, could be chosen as evaluation methods for the in vitro release of Zhike Pingchuan sustained-release tablets.</p>