Chemical constituents of Alisma orientalis and their immunosuppressive function / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 994-998, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-263084
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents with immunosuppressive function from Alisma orientalis.</p><p><b>METHOD</b>The chemical constituents were isolated and purified by kinds of column chromatography and its structures were elucidated by NMR spectra and physicochemical properties. Its immunocompentence of lymphocytes taken from spleen of mouse were examined by MTT assay.</p><p><b>RESULT</b>Twelve compounds were isolated and identified as clovandiol (1), orientalol E (2), alismoxide (3), alismol (4), 4alpha, l0alpha-dihydroxy-5beta-H-guaj-6-en (5), alismorientols A (6), alisol F (7), alisol A (8), 13beta,17beta-epoxy alisol A (9), alisol B 23-acetate (10), 1H-indole-3-carboxylic acid (11) and cuccinic acid (12). Compounds 9, 10 and alisol A 24-acetate showed immunosuppressive function.</p><p><b>CONCLUSION</b>Compounds 1, 5, 11 and 12 were isolated firstly from this genus,and the NMR spectra data of 1 were corrected firstly, some protostan-type triterpenoids may be developed as new drug with immunosuppressive function.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Sesquiterpenes
/
Triterpenes
/
Drugs, Chinese Herbal
/
Magnetic Resonance Spectroscopy
/
T-Lymphocytes
/
Cells, Cultured
/
Chemistry
/
Cholestenones
/
Cell Biology
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS