Studies on chemical constituents in fruit of Alpinia oxyphylla / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 990-993, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-263085
ABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents in fruit of Alpinia oxyphylla and their cytotoxicities on cancer cell lines.</p><p><b>METHOD</b>Compounds were isolated and purified by various column chromatographic methods. Their structures were determined by physico-chemical properties and spectral analyses. Compound cytotoxicity was assessed by the sulforhodamine B (SRB) assay.</p><p><b>RESULT</b>Eight compounds were obtained from Me2CO-H2O (70%) extract of the fruit of A. oxyphylla and their structures were identified as (9E)-humulene-2, 3; 6, 7-diepoxide (1), 3(12), 7(13), 9(E)-humulatriene-2, 6-diol (2), (-)-oplopanone (3), yakuchinone A (4), yakuchinone B (5), tectochrysin (6), isovanillin (7), (2E, 4E)-6-hydroxy-2, 6-dimethylhepta-2, 4-dienal (8), and the cytotoxicities of compounds 1, 3-5 on cancer cell lines, A549, HT-29 and SGC-7901, were also investigated.</p><p><b>CONCLUSION</b>Compounds 1-3, 7, 8 were isolated for the first time from this genus and compounds 1, 3-5 exhibited no cytotoxicity against three cancer cell lines at a concentration of 10 mg x L(-1).</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Benzaldehydes
/
Flavonoids
/
Drugs, Chinese Herbal
/
Cell Survival
/
Chemistry
/
HT29 Cells
/
Alpinia
/
Diarylheptanoids
/
Cell Line, Tumor
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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