In vitro study of immunosuppressive effect of apoptotic cells / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 919-925, 2005.
Article
in English
| WPRIM
| ID: wpr-263276
ABSTRACT
Recent studies revealed that apoptotic cells are actively involved in immunosuppression and anti-inflammation. After being phagocytosed by macrophages, apoptotic cells can actively regulate cytokines secretion from lipopolysaccharide (LPS)-stimulated macrophages, in which the secretion of immunosuppressive cytokines such as interleukin-10 (IL-10) is increased while the pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFa), interleukin-1beta (IL-1b) and leukin-8 (IL-8) are suppressed. In this paper, we first present evidence that phagocytosed apoptotic cells regulate cytokine secretion of LPS-stimulated macrophages, but also inhibit the activation of T lymphocytes stimulated by ConA. These data suggest that apoptotic cells can alter the biological behavior of macrophages which gain immunosuppressive property.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phagocytosis
/
Pharmacology
/
In Vitro Techniques
/
Lymphocyte Activation
/
T-Lymphocytes
/
Receptors, Interleukin-2
/
Signal Transduction
/
Antigens, Differentiation, T-Lymphocyte
/
Antigens, CD
/
Lipopolysaccharides
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2005
Type:
Article
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