Expression of transforming growth factor-β1 and its receptors in peripheral blood of patients with immune thrombocytopenic purpura / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 664-666, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-263327
ABSTRACT
This study was purposed to detect the expression of transforming growth factor β1 (TGF-β1) and its receptors (TGF-βR) and to investigate their roles in pathogenesis of immune thrombocytopenic purpura (ITP). The expressions of TGF-β1 and their receptors TGF-βRI, TGF-βRII and TGF-βRIII in the peripheral blood of patients with ITP and healthy persons were detected by the real-time PCR, and differences of their expression levels were analysed. The results showed that the expression of TGF-β1 and TGF-βRII mRNA in ITP patients was significantly higher than that in the healthy controls, while the TGF-βRI mRNA expression in ITP patient was significantly lower than that in the controls. The expression of TGF-βRIII was not statistically different between the two groups. It is concluded that TGF-β1 and its receptors including TGF-βRI and TGF-βRII express abnormally in the peripheral blood of ITP patients, which suggests that the TGF-β signaling pathway probably play a vital role in the pathogenesis of the ITP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Case-Control Studies
/
Purpura, Thrombocytopenic, Idiopathic
/
Protein Serine-Threonine Kinases
/
Receptors, Transforming Growth Factor beta
/
Transforming Growth Factor beta1
/
Metabolism
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2012
Type:
Article
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