Advancement of insulin effecting signaling pathway of leukemia cell proliferation / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 514-517, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-263360
ABSTRACT
Many reports have documented a role of insulin and insulin-like growth factor 1 (IGF-1) as growth factors in many cancers. The sequence and structure of insulin receptor (IR) and IGF receptor (IGF-1R) are highly similar. Both receptors are overexpressed in leukemia cells.Studies indicate that insulin can enhance the signal of the phosphoinositide 3-kinase/Akt pathways by activating IR or IGF-1R or hybrid IR/IGF-IR receptors, resulting in the proliferation of leukemia cells. High concentration of insulin may inhibit the growth of leukemia cells, the mechanism of which remains to be unclear. Inhibiting IR and IGF-IR can diminish the proliferation of leukemia cells. Therefore, the assumption of IR/IGF-1R as a potential therapeutic target in leukemia appears reasonable. This article summarizes the recent advancement associated with the signaling pathway of insulin effecting the proliferation of leukemia cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Insulin-Like Growth Factor I
/
Receptor, Insulin
/
Signal Transduction
/
Leukemia
/
Cell Line, Tumor
/
Cell Proliferation
/
Insulin
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2012
Type:
Article
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