Influence of S-nitrosoglutathione on agglutination and nitric oxide concentration in frozen platelets / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 386-389, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-263386
ABSTRACT
The aim of this study was to investigate the influence of S-nitrosoglutathione (GSNO) on agglutination and nitric oxide (NO) concentration in frozen platelets. The agglutination of platelets was detected by using platelet agglutination apparatus, the level of NO in platelets was detected by the nitrate enzyme reduction method. The results showed that the rates of agglutination in freeze platelets and frozen platelets treated with GSNO were (35.47 ± 2.93) and (24.43 ± 3.07), which were significantly lower than that in fresh liquid platelets (63.44 ± 2.96). The level of NO concentration in frozen platelets was (22.16 ± 6.38), which was significantly lower than that in fresh liquid platelets (31.59 ± 16.88). The level of NO concentration in frozen platelets treated with GSNO was (45.64 ± 6.31), which was significantly higher than that in fresh liquid platelets (P < 0.01). It is concluded that GSNO increases the concentration of NO in frozen platelets, inhibits platelet activation and maintains platelet function, thus GSNO can be used as a frozen protective agent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Platelet Count
/
Blood Platelets
/
Platelet Activation
/
Platelet Aggregation
/
S-Nitrosoglutathione
/
Freezing
/
Metabolism
/
Nitric Oxide
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2012
Type:
Article
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