Mandibular fracture fixed with PDLLA/nano-HA compound plates: an animal study / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the applicability of PDLLA/nano-HA compound plates used in internal fixation of mandibular fractures.</p><p><b>METHODS</b>Rabbit mandibular fracture model was used in this study. Clinical observation, the amount of callus, histological observation were studied and compared with PDLLA plates.</p><p><b>RESULTS</b>All fractures were fixed rigidly. There was 1 animal experienced local inflammation and then forming fistula in the side of PDLLA plate at postoperative 2 and 3 weeks. No side-effects were found in the side of compound plates. During the early stage of bone healing, the quality of callus in the side of compound plates was apparently more than that in the other side, and histological study showed that the osteoblasts and fibroblasts were more active in the side of compound plate in the early healing stage.</p><p><b>CONCLUSIONS</b>PDLLA/nano-HA compound plate has a proper degradation time. Compared with PDLLA plates, it is more effective and safer when used in mandibular fracture.</p>