Novel role of microRNAs in prostate cancer / 中华医学杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To discuss the novel biomarkers of microRNAs in prostate cancer.</p><p><b>DATA SOURCES</b>The literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012.</p><p><b>STUDY SELECTION</b>Original articles regarding the novel role of microRNAs in prostate cancer were selected.</p><p><b>RESULTS</b>MicroRNAs play an important role in prostate cancer such as cell differentiation, proliferation, apoptosis, and invasion. Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), drug sensitivity, cancer microenvironment, energy metabolism, androgen independence transformation, and diagnosis prediction.</p><p><b>CONCLUSIONS</b>MicroRNAs are involved in various aspects of prostate cancer biology. The role of microRNA in the initiation and development of prostate cancer deserves further study.</p>