Polymorphism distribution of HLA-DRB1 gene locus in Han race population in Liaoning of China / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 349-351, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-263777
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the genotype distribution of HLA-DRB1 polymorphisms in the Han race population in Liaoning of China and to evaluate its value on forensic medicine.</p><p><b>METHODS</b>The blood DNA samples from 13265 unrelated Chinese individuals of Han race population in Liaoning province were investigated and HLA-DRB1 alleles were genotyped with PCR-SSP and PCR-SSOP in low resolution level.</p><p><b>RESULTS</b>Thirteen HLA-A alleles were found, in which HLA-DRB1*15, 09, 12, 07 were the commonest but HLA-DRB1*03(18), HLA-DRB1*14(8) were absent. The population data conformed to the Hardy-Weinberg equilibrium(chi-square was 73.34, df was 78, P> 0.5). The exclusion probability of paternity was 64.7%, the power of discrimination was 97.9% and the heterozygosity was 89.4%.</p><p><b>CONCLUSION</b>The HLA-DRB1 polymorphism of Liaoning Han populations show the special characters and HLA-DRB1 genotyping is useful genetic marker to paternity testing and personal identification.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
HLA-DR Antigens
/
Linkage Disequilibrium
/
China
/
Polymerase Chain Reaction
/
HLA-DRB1 Chains
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS