Allelic polymorphism analysis of killer cell immunoglobulin-like receptor gene 3DL2 in Zhejiang Han population / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 339-342, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-263780
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the allelic polymorphism of killer cell immunoglobulin (Ig)-like receptor (KIR) gene 3DL2 in Zhejiang Han population.</p><p><b>METHODS</b>Allelic definition within KIR3DL2 was achieved through using the PCR-sequence specific oligonucleotide probes (PCR-SSOP) method and the specific amplification of exon 3-exon 4 and exon 8-exon 9. Twenty-one digoxigenin-labelled probes were used to the SSOP analysis.</p><p><b>RESULTS</b>Seven alleles of KIR3DL2 were observed, in which KIR3DL2 *002 had the highest allele frequency, 0.57. One sample could not be given the allele combination according to the probe profile.</p><p><b>CONCLUSION</b>The PCR-SSOP method was reliable. There is a distinctive allele frequency of KIR3DL2 in Zhejiang Han population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
China
/
Polymerase Chain Reaction
/
Sequence Analysis, DNA
/
Asian People
/
Receptors, KIR3DL2
/
Gene Frequency
/
Genetics
/
Genetics, Population
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Type:
Article
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