The correlation between ICAM-1 gene K469E polymorphism and coronary heart disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 205-207, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-263816
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between intercellular adhesion molecule1 (ICAM1) gene K469E polymorphism and coronary heart disease(CHD) in Han Chinese population.</p><p><b>METHODS</b>Using the methods of polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP), 173 CHD patients and 141 controls were analyzed for the polymorphism, genotype and allele distribution of ICAM1 gene K469E.</p><p><b>RESULTS</b>The distribution of ICAM1 genotypes was in Hardy-Weinberg equilibrium. The frequency of KK genotype in CHD group was significantly higher than that in control (64.2% vs 48.9%, P<0.01). Similarly, the frequency of K allele in CHD group was significantly higher than that in control (79.2% vs 69.9%, P<0.01). With Logistic Regression Analysis ruling out the influences of age, gender and other CHD risk factor, the homozygous individual with KK genotype was 2.35 folds of KE or EE genotype one suffering from CHD (OR 2.35, 95%CI 1.03-5.36, P<0.05).</p><p><b>CONCLUSION</b>ICAM1 gene K469E polymorphism is associated with CHD risk of Han Chinese population, the K allele may serve as a genetic risk factor of coronary heart disease.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Logistic Models
/
Risk Factors
/
Intercellular Adhesion Molecule-1
/
Coronary Disease
/
Amino Acid Substitution
/
Genetic Predisposition to Disease
/
Asian People
/
Genetics
/
Genotype
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2006
Type:
Article
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