HLA-DRB1 polymorphism in the Ewenki Ethnic of Inner Mongolian / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the HLA-DRB1 genetic polymorphism in the Ewenki of Inner mongolia.</p><p><b>METHODS</b>HLA-DRB1 allele polymorphisms in 84 normal Ewenki were determined by PCR with sequencing based typing (SBT).</p><p><b>RESULTS</b>Twenty-five HLA-DRB1 alleles were observed. The allele frequency of HLA-DRB1*03011(14.88%) is the highest; the allele frequencies of HLA -DRB1*09012 (13.69%), DRB1*07011(8.92%), DRB1*04011(9.52%) and DRB1*12011(8.33%) are lower.</p><p><b>CONCLUSION</b>The distribution of HLA-DRB1 alleles frequencies in normal Ewenki from Inner Mongolia exhibits a unique profile, which is of important reference value for studies on anthropology and related illnesses in Ewenki population.</p>