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Expressions of short palate, lung and nasal epithelium clone 1 in different human tissues / 南方医科大学学报
Article in Zh | WPRIM | ID: wpr-263993
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To examine the expression patterns of short palate, lung and nasal epithelium clone 1 (SPLUNC1) gene in human tissues.</p><p><b>METHODS</b>In situ hybridization was used to detect the expression of SPLUNC1 gene in 37 different human tissues.</p><p><b>RESULTS</b>We found that SPLUNC1 gene was not expressed in squamous epithelial cells of the palate, epidermis, esophagus, or the esophagus-cardia junction, metaplastic squamous cells in the nasopharynx, trachea, or uterus cervix, or tumor cells of esophageal squamous cell carcinoma or lung squamous cell carcinoma. SPLUNC1 gene was not expressed in the single layer columnar epithelia cells in the stomach, gallbladder, jejunum, colon, endometrium, or uterus cervix. SPLUNC1 expression was detected mainly in pseudostratified columnar epithelial cells in the nasopharynx, trachea and bronchi, and was gradually down-regulated from the upper to lower end of the respiratory tract, but was not detected in the lung tissues. SPLUNC1 expression was detected not only in the duct and serous gland cells in the parotid and submandibular glands, but also in cells of submucosal serous glands in the nasopharynx and lung, but not in the cells of the mucosal glands. The parietal cells of the gastric submucosa and epithelial cells of the lobula and ducts of the mammary glands expressed SPLUNC1. The adenocarcinoma cells in the lung, stomach, colon, mammary gland, uterus endometrium and cervix showed strong expressions of SPLUNC1 gene.</p><p><b>CONCLUSION</b>SPLUNC1 expression is highly cell-specific in association with the cell functions.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Organ Specificity / Phosphoproteins / Glycoproteins / Gene Expression / Epithelial Cells / Genetics / Metabolism Limits: Humans Language: Zh Journal: Journal of Southern Medical University Year: 2016 Type: Article
Full text: 1 Index: WPRIM Main subject: Organ Specificity / Phosphoproteins / Glycoproteins / Gene Expression / Epithelial Cells / Genetics / Metabolism Limits: Humans Language: Zh Journal: Journal of Southern Medical University Year: 2016 Type: Article