Value of lymphocyte count in assessing cellular immune function in patients with community-acquired pneumonia / 南方医科大学学报
Journal of Southern Medical University
;
(12): 273-276, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-264057
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the value of lymphocyte count in assessing cellular immune function in patients with community-acquired pneumonia.</p><p><b>METHODS</b>Ninety-three patients with community-acquired pneumonia (including 53 non-severe and 40 severe cases) and 52 healthy adults were examined for routine blood test and T lymphocyte count. Blood lymphocyte counts and absolute T lymphocyte counts were compared among the 3 groups and their correlation was analyzed.</p><p><b>RESULTS</b>Compared with the healthy control subjects, patients with community-acquired pneumonia showed significantly lower blood lymphocyte counts and CD3(+), CD4(+), and CD8(+) levels (P<0.05). CD3(+), CD4(+), and CD8(+) levels were positively correlated with blood lymphocyte counts. With blood lymphocyte count as the independent variable (L), and the regression equations for CD3(+), CD4(+), and CD8(+) levels were CD3(+)=485.45L+313.48 (F=59.68, P<0.01), CD4(+)=192.57L+290.11 (F=24.62, P<0.01), and CD8(+)=275.14L+18.04 (F=23.46, P<0.01) in the control group; CD3(+)=564.15L+25.04 (F=96.56, P<0.01), CD4(+)=381.91L-37.45 (F=68.60, P<0.01), and CD8(+)=165.61L+61.83 (F=55.47, P<0.01) in non-severe pneumonia group; and CD3(+)=565.44L+49.09 (F=31.87, P<0.01), CD4(+)=332.34L-17.37 (F=43.64, P<0.01), and CD8(+)=223.46L+54.39 (F=13.90, P<0.01) in severe pneumonia group.</p><p><b>CONCLUSION</b>Patients with community-acquired pneumonia have decreased cellular immune function. Absolute T lymphocyte count can be estimated by blood lymphocyte count to save the cost of laboratory tests.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Case-Control Studies
/
T-Lymphocyte Subsets
/
Community-Acquired Infections
/
Lymphocyte Count
/
Cell Biology
/
Allergy and Immunology
Type of study:
Observational study
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2016
Type:
Article
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