Methodology for the assessment of burden of smear-positive pulmonary TB and its infectivity / 生物医学与环境科学（英文）

ABSTRACT

<p><b>OBJECTIVE</b>The study investigated the burden of smear-positive pulmonary TB and its infectivity using DALY (disability-adjusted life year) as an indicator.</p><p><b>METHODS</b>An assumed cohort of 2,000 cases was set up based on the age-specific incidence of 794 newly registered smear-positive cases in Beijing in 1994. Prognostic trees and model diagrams of infectivity under natural history and DOTS(directly observed treatment, short-course) strategy were established according to the epidemiological evidence.</p><p><b>RESULTS</b>The results showed that 29.6% of DALYs would be neglected if the burden caused by the infectivity was not considered.</p><p><b>CONCLUSION</b>DOTS strategy may reduce 97.3% of the number of potential cases infected, 92.9% of DALYs related to TB-patients themselves, and 99.9% of DALYs caused by TB's infectivity as well.</p>