The prognostic value of human neuroendocrine clone on colorectal carcinoma / 中华外科杂志
Chinese Journal of Surgery
;
(12): 706-709, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-264440
ABSTRACT
<p><b>OBJECTIVE</b>To demonstrate the prognostic value of neuroendocrine clone on colorectal carcinoma.</p><p><b>METHODS</b>The immunochemistry methods were used to investigate the percent of neuroendocrine carcinoma in 73 human colorectal carcinoma. Retrospective analysis and follow-up were carried out in all patients.</p><p><b>RESULTS</b>In all 73 cases of colorectal carcinoma, the total percentage of neuroendocrine carcinoma was 17.8%. Neuroendocrine carcinoma included 11 synapse positive, 6 chromogranin positive and 4 both positive. The major factors related to the prevalence of neuroendocrine carcinoma were sex, age, tumor location and Dukes' stage. And the 1-year survival rate of the patients who suffered from neuroendocrine carcinoma is obviously lower than that of other colorectal carcinoma.</p><p><b>CONCLUSIONS</b>The neuroendocrine carcinoma is a special kind of human colorectal carcinoma, and neuroendocrine clone may be a new marker of the malignant potency. The neuroendocrine clone has its prognostic value and may be a novel therapeutic target.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Colorectal Neoplasms
/
Survival Rate
/
Retrospective Studies
/
Mortality
/
Chromogranins
/
Synapsins
/
Carcinoma, Neuroendocrine
/
Metabolism
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2005
Type:
Article
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