Short-term neoadjuvant hormone therapy enhanced expression of clusterin in prostate cancer / 中华外科杂志
Chinese Journal of Surgery
;
(12): 394-397, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-264499
ABSTRACT
<p><b>OBJECTIVE</b>To define changes in clusterin expression following short-term neoadjuvant hormone therapy (NHT) and its biological significance in prostate cancer tissues.</p><p><b>METHODS</b>Twenty-six archival radical prostatectomy (RP) specimens without receiving NHT, 19 needle biopsies and corresponding 19 RP specimens following 3-month NHT, were subjected to immunohistochemical clusterin staining.</p><p><b>RESULTS</b>Staining for clusterin was mainly found in cytoplasm and part of extracellular matrix. Clusterin expression was significantly greater in RP specimens with preoperative NHT (t = 2.91, P < 0.01); Needle biopsies obtained before NHT consistently demonstrated lower staining intensity (1.42 +/- 0.51) than corresponding RP specimens (2.16 +/- 0.60) following 3-month NHT (t = 7.10, P < 0.01).</p><p><b>CONCLUSIONS</b>Upregulation of clusterin in part accounts for malignant progression of prostate cancer through its anti-apoptotic action following androgen withdrawal. These findings support that adjuvant therapy targeting clusterin may enhance androgen ablation therapy in advanced prostate cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostatic Neoplasms
/
Therapeutics
/
Immunohistochemistry
/
Oligonucleotides, Antisense
/
Neoadjuvant Therapy
/
Therapeutic Uses
/
Clusterin
/
Genetics
/
Metabolism
Limits:
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2005
Type:
Article
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