The Epidemiological Characteristics of Beijing Lineage Mycobacterium tuberculosis from a National Referral Center in China / 生物医学与环境科学（英文）
Biomedical and Environmental Sciences
;
(12): 539-543, 2015.
Article
in English
| WPRIM
| ID: wpr-264549
ABSTRACT
Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 and 51 SNP loci and VNTR. The high differentiation SNPs of modern Beijing strains were analyzed for protein function and structure. 413 M. tuberculosis were included. Of 379 Beijing lineage M. tuberculosis, 'modern' and 'ancient' strains respectively represented 85.5% (324/379) and 14.5% (55/379). Rv2494 (V48A) and Rv0245 (S103F) were confirmed as high differentiation SNPs associated with modern strains. In a word, Modern Beijing lineage M.tuberculosis was dominant and the structural models suggested that modern sub-lineage may more easily survive in 'extreme' host condition.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Tuberculosis
/
DNA, Bacterial
/
China
/
Epidemiology
/
Classification
/
Genome, Bacterial
/
Molecular Epidemiology
/
Polymorphism, Single Nucleotide
/
Phylogeography
Type of study:
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2015
Type:
Article
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