A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou, China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 535-538, 2015.
Article
in English
| WPRIM
| ID: wpr-264550
ABSTRACT
In this study, we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate (NSCLP) to understand the etiology of the disease. A total of 200 NSCLP cases and 327 controls were recruited at the Maternal and Child Health Hospital of Xuzhou City. We conducted face-to-face interviews with the mothers of both cases and controls. The factors increasing the risk of NSCLP were a positive family history [odds ratio (OR)=56.74], pesticide exposure (OR=8.90), and indoor decoration pollution (OR=4.32). On the other hand, the factors decreasing the risk of NSCLP were a high education level (OR=0.22) and supplementation of folic acid (OR=0.23) and multivitamins (OR=0.16). Positive family history, pesticide exposure, and indoor decoration pollution are associated with the risk of NSCLP. In contrast, high education level and folic acid and multivitamin supplementation are protective factors against NSCLP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Socioeconomic Factors
/
Case-Control Studies
/
Logistic Models
/
China
/
Epidemiology
/
Surveys and Questionnaires
/
Risk Factors
/
Cleft Lip
/
Cleft Palate
/
Maternal Exposure
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Qualitative research
/
Risk factors
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2015
Type:
Article
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