Benchmark Dose Estimation for Cadmium-Induced Renal Effects Based on a Large Sample Population from Five Chinese Provinces / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 383-387, 2015.
Article
in English
| WPRIM
| ID: wpr-264572
ABSTRACT
A survey involving 6103 participants from five Chinese provinces was conducted to evaluate the threshold value of urinary cadmium (UCd) for renal dysfunction as benchmark dose low (BMDL). The urinary N-acetyl-β-D-glucosaminidase (UNAG) was chosen as an effect biomarker. The UCd BMDLs for UNAG ranged from 2.18 μg/g creatinine (cr) to 4.26 μg/g cr in the populations of different provinces. The selection of the sample population and area affect the evaluation of the BMDL. The reference level of UCd for renal effects was further evaluated based on the data of all 6103 subjects. With benchmark responses (BMR) of 10%/5%, the overall UCd BMDLs for males in the total population were 3.73/2.08 μg/g cr. The BMD was slightly lower in females, thereby indicating that females may be relatively more sensitive to Cd exposure than are males.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urine
/
Cadmium
/
China
/
Population Surveillance
/
Epidemiology
/
Creatinine
/
Dose-Response Relationship, Drug
/
Environmental Pollutants
/
Toxicity
/
Kidney Diseases
Type of study:
Screening study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS