The Association between Folate Pathway Genes and Cleft Lip With or Without Cleft Palate in a Chinese Population / 生物医学与环境科学（英文）
Biomedical and Environmental Sciences
;
(12): 136-139, 2015.
Article
in English
| WPRIM
| ID: wpr-264610
ABSTRACT
NSCL/P is a common congenital defect and gene-environmental factors involve in this disorder. Periconceptional intake of folate may reduce the risk of NSCL/P. The present study investigated three SNPs (rs1801198, rs955516, and rs3733890) in three folate pathway genes, including TCN2, MTR, and BHMT among 481 patients and 558 healthy subjects. Rs955516 showed allelic association with NSCL/P. More patients carry rs955516 AA and rs3733890 AA genotypes. The gene-gene interaction test showed trans-phase combination effects for MTR and BHMT genes. Our study suggests that the interaction of MTR and BHMT genes play a vital role in the pathogenesis of NSCL/P in Chinese population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Congenital Abnormalities
/
Brain
/
China
/
Epidemiology
/
Cleft Lip
/
Cleft Palate
/
Polymorphism, Single Nucleotide
/
Folic Acid
/
Genetics
/
Genotype
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2015
Type:
Article
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