Intersectin 1: a molecular linker in the central nervous system / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 401-405, 2008.
Article
in English
| WPRIM
| ID: wpr-264649
ABSTRACT
Down syndrome (DS) is the most common cause of cognitive impairment associated with a congenital chromosomal abnormality, trisomy of chromosome 21. Mental retardation and congenital heart defects are key features of DS. All DS individuals develop early-onset Alzheimer's disease-like neuropathology. Intersectin 1 gene is localized on human chromosome 21, the critical region of DS, and it has higher expression in the brain of DS patients than in normal individuals. So fully understanding functions of intersectin 1 is critical for revealing the pathogenesis of DS. Intersectin 1 protein has two isoforms intersectin 1-L and intersectin 1-S. This review will focus on the distribution, expression characters and functions of intersectin 1 in the central nervous system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chromosomes, Human, Pair 21
/
Central Nervous System
/
Cell Biology
/
Adaptor Proteins, Vesicular Transport
/
Genetics
/
Mental Disorders
/
Metabolism
/
Neurons
Type of study:
Diagnostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2008
Type:
Article
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