Migraine as a sex-conditioned inherited disorder: evidences from China and the world / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 110-116, 2008.
Article
in English
| WPRIM
| ID: wpr-264688
ABSTRACT
Migraine is a complex and heterogeneous disorder. Although several genetic models has been proposed including autosomal-dominant/autosomal recessive, sex-linked, sex-limited, mitochondrial, and multi-gene, none of these models can well-explain the transmission of the disease. We hypothesied that migraine is a sex-conditioned inherited disorder (autosomal dominant in females and autosomal recessive in males). This hypothesis is supported by the evidence such as the locations of genes associated with familial hemiplegic migraine, possibly "typical" migraine as well (dominantly on chromosome 19p, 1q, and 2q), malefemale ratio of prevalence (12-14), the mostly youth-onset, the provocation by the contraceptives, the induction by menstruation, and the self-limitation after menopause. Female sex-hormones appear to be the key contributor to a higher prevalence of migraine in female. Socio-environmental factors may also play an important role.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gonadal Steroid Hormones
/
China
/
Sex Factors
/
Epidemiology
/
Age of Onset
/
Genetic Predisposition to Disease
/
Inheritance Patterns
/
Genes, Dominant
/
Genetics
/
Menstrual Cycle
Type of study:
Prognostic study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Neuroscience Bulletin
Year:
2008
Type:
Article
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