Alzheimer's disease: epidemiology, genetics, and beyond / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 105-109, 2008.
Article
in English
| WPRIM
| ID: wpr-264689
ABSTRACT
Alzheimer's disease (AD) is an increasing epidemic threatening public health. Both men and women are susceptible to the disease although women are at a slightly higher risk. The prevalence of AD rises exponentially in elderly people from 1% at age of 65 to approximately 40%-50% by the age of 95. While the cause of the disease has not been fully understood, genetics plays a role in the onset of the disease. Mutations in three genes (APP, PSEN1, and PSEN2) have been found to cause AD and APOE4 allele increases the risk of the disease. As human genomic research progresses, more genes have been identified and linked with AD. Genetic screening tests for persons at high risk of AD are currently available and may help them as well as their families better prepare for a later life with AD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aging
/
Genetic Testing
/
Epidemiology
/
Risk Factors
/
Amyloid beta-Protein Precursor
/
Genetic Predisposition to Disease
/
Diagnosis
/
Apolipoprotein E4
/
Presenilins
/
Alzheimer Disease
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Aged
/
Aged80
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2008
Type:
Article
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