Roles of NF-kappaB in central nervous system damage and repair / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 307-313, 2007.
Article
in English
| WPRIM
| ID: wpr-264708
ABSTRACT
NF-kappaB family is a kind of nuclear factors in B lymphocyte that can bind to the immunoglobulin kappa-chain enhancer and enhance transcriptional activity. NF-kappaB/Rel proteins, as a dimeric transcription factor, control the expression of genes that regulate a broad range of biological processes through canonical and non-canonical pathways. In the central nervous system, NF-kappaB controls inflammatory reactions and the apoptotic cell death following nerve injury. It also contributes to the infarction and cell death in stroke models and patients. However, NF-kappaB is essential for neurosurvival as well. NF-kappaB activation is a part of recovery process that may protect neurons against oxidative-stresses or brain ischemia-induced apoptosis and neurodegeneration. Inhibition of NF-kappaB may reduce its neuroprotection activity. Hence the dual opposite effects of NF-kappaB on cells. The ultimate survival or death of neurons depends on which, where and when the NF-kappaB factors are activated.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Wounds and Injuries
/
Central Nervous System
/
NF-kappa B
/
Metabolism
/
Nerve Regeneration
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2007
Type:
Article
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