Expression of the tyrosine kinase receptor EphA5 and its ligand ephrin-A5 during mouse spinal cord development / 神经科学通报·英文版

ABSTRACT

<p><b>OBJECTIVES</b>To study the expression patterns of two Eph family molecules, the receptor EphA5, and the ligand ephrin-A5, during spinal cord development.</p><p><b>METHODS</b>The receptor expression was analyzed using beta-galactosidase knockin mice, and affinity ligand probe binding. The ligand expression was assessed using two different affinity probes, and knockout mouse tissues as controls.</p><p><b>RESULTS</b>EphA5 was expressed in the ventral spinal cord, while ephrin-A5 was located in the dorsolateral regions of the spinal cord throughout development.</p><p><b>CONCLUSIONS</b>These results show that EphA5 and ephrin-A5 are expressed over broad developmental stages and may play important roles in establishing the dorsoventral organization of the spinal cord.</p>