Pathogenesis of hilar cholangiocarcinoma and infection of hepatitis virus / 中华外科杂志
Chinese Journal of Surgery
;
(12): 420-422, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-264805
ABSTRACT
OBJECTIVE To study the correlation between hepatic hilar cholangiocarcinoma and the infection of HB (C)V. METHODS Combined with clinical data, immunohistochemistry was used to detect HBXAg antigen and HCV-C protein in 68 formalin-fixed and paraffin-embedded samples of hilar cholangiocarcinoma. RESULTS Six cases(8.8%) were positive to HBXAg antigen and 24 cases (35.0%) to HCV-C protein respectively. One case was positive to both HBXAg antigen and HCV-C protein. There were statistical differences in differentiation and invasion, lymph node metastasis, treatment between hilar cholangiocarcinomas infected HB(C)V and those non-infected. CONCLUSIONS HBXAg antigen and HCV-C protein may play an important role in the pathogenesis of hilar cholangiocarcinoma. Hilar cholangiocarcinoma infected HB(C)V may have a high malignancy and more poor prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bile Duct Neoplasms
/
Bile Ducts, Intrahepatic
/
Trans-Activators
/
Viral Core Proteins
/
Hepatitis C
/
Cholangiocarcinoma
/
Hepatitis B
Type of study:
Etiology study
/
Prognostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2002
Type:
Article
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