Studies on pharmacokinetics of artemether patch in mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1459-1462, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-264855
ABSTRACT
<p><b>OBJECTIVE</b>To establish a HPLC-MS-MS determination method of artemether (ARM) and active derivatives DHA, and compare the pharmacokinetic parameters of ARM after transdermal and oral administration.</p><p><b>METHOD</b>The mice were divided two groups (transdermal and oral) by parallel design. ARM and active derivatives DHA in plasma of mice at different sampling time were determined. The pharmacokinetic parameters were calculated by DAS 2.0 and by statistic analysis.</p><p><b>RESULT</b>compare oral administration, the pharmacokinetic parameters of ARM after transdermal, Cmax Tmax , AUC(0-t) MRT, had significant difference (P < 0.05).</p><p><b>CONCLUSION</b>The artemether patch has long-releasing property.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Administration, Cutaneous
/
Calibration
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Administration, Oral
/
Chromatography, High Pressure Liquid
/
Sensitivity and Specificity
/
Artemisinins
/
Tandem Mass Spectrometry
Type of study:
Diagnostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Type:
Article
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