Drug release of sustained-released tablets of total Puerariae flavones / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study drug release of sustained-released tablets of total puerariae flavones and investigate the evaluating method of sustained released preparations Chinese material medica sustained-released preparation.</p><p><b>METHOD</b>Rotating basket method and HPLC were employed to assess the characteristics of multi-component.</p><p><b>RESULT</b>Under the selected chromatographic conditions, good HPLC fingerprint of the release of sustained-released tablets of total puerariae flavones were obtained. Through the determination of 8 time-point samples,the release of sustained-released tablet of total puerariae flavones had a well-balanced release behavior.</p><p><b>CONCLUSION</b>The HPLC-UV fingerprint method was simple and reproducible, quality of tablets of total puerariae flavones can be controlled effectively by the method. The method could be applied to evaluate the release of sustained-released tablets of total puerariae flavones.</p>