A new cycloartane triterpene saponin from rhizome of Actaea asiatica / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1558-1561, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-264897
ABSTRACT
<p><b>OBJECTIVE</b>To isolate and elucidate the chemical constituents with the cytotoxicity activity from the rhizome of Actaea asiatica.</p><p><b>METHOD</b>The chemical constituents were isolated by repeated column chromatography (Toyopearl HW40C and preparative HPLC) and the structure of compound 1 was elucidated by spectral data analysis.</p><p><b>RESULT</b>A cycloartane triterpene saponin com- pound was isolated and identified to be (23R)-16beta, 23 23alpha, 26 24alpha 25-triepoxy-9, 19-cyclolanost-7-en-3beta-O-beta-D-xylopyranoside.</p><p><b>CONCLUSION</b>Compound 1 was a new compound and named (23R)-26-deoxycimicifugoside. The IC50 values of compound 1 for cell growth inhibition of Hela and L929 cell lines were 72.24 and 55.97 mg x L(-1), respectively.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Saponins
/
Chemistry
/
Plant Structures
/
Actaea
/
Cell Line, Tumor
/
Cell Proliferation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Type:
Article
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