Research progress on B lymphocyte-induced maturation protein 1 and its relationship with the development of lymphoma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1623-1626, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-264964
ABSTRACT
Many studies show that as a transcription factor, B lymphocyte-induced maturation protein 1 (Blimp 1) is the master regulator of plasma-cell differentiation. The abnormality of Blimp 1 plays an important part in the genesis and development of lymphoma. This review introduces and summarizes Blimp 1's protein structure and functions, its role in B cell differentiation, its main target genes and the mechanism of its transcriptional repressor activity. Besides, the relationship between Blimp 1 gene mutation or Blimp 1 protein expression reduction and the development of DLBCL is preliminary summaried.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Repressor Proteins
/
Transcription Factors
/
B-Lymphocytes
/
Cell Differentiation
/
Lymphoma, Large B-Cell, Diffuse
/
B-Cell Maturation Antigen
/
Positive Regulatory Domain I-Binding Factor 1
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
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