Mechanism and early evaluation of CNS infiltration in acute lymphocytic leukemia-review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1361-1364, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-265013
ABSTRACT
Central nervous system (CNS) is one of places in which direct infiltration and involvement or relapse occur in adult lymphocytic leukemia. The main mechanism of CNS infiltration in leukemia is associated with blood brain barrier (BBB), however the ALL CNS infiltration is difficulty early predicted and evaluated.For this reason, the studies on accurately evaluating the ALL CNS infiltration have important significance for early diagnosis and adjustment of therapeutic regimen, performance of individualised treatment and improvement of ALL patient's prognosis. In this article, the pathway of ALL CNS infiltration and its molecular mechanism, the evaluation methods for BBB function are reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Blood-Brain Barrier
/
Central Nervous System Neoplasms
/
Early Diagnosis
/
Diagnosis
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Neoplasm Invasiveness
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS