MicroRNA as potential target for gene therapy of multiple myeloma-review / 中国实验血液学杂志

ABSTRACT

The studies in recent years have found that miRNA play an important role in various biological functions, such as cell differentiation, proliferation, apoptosis, migration, and survival. Many studies considered the abnormally expressed miRNA as significant regulator in the pathogenesis, progression and metastasis of malignant tumors. miRNA can function as oncogenes or tumor suppressors by regulating post-transcriptional factors effecting multi pathways and may even represent target for therapies. This review summarizes the current advancement about the roles of miRNA in the biology of multiple myeloma (MM), including focuses on miRNA signatures relevant to MM, functions of critical miRNA in the mechanisms and development of MM behind their deregulation, the role in the drug-resistance and perspective of their expression in MM.