Study on mitochondrial DNA damage in peripheral blood nucleate cells of the workers exposed to acrylonitrile / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 99-101, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-265046
ABSTRACT
<p><b>OBJECTIVE</b>To study the potential aging effect on workers exposed to acrylonitrile (ACN).</p><p><b>METHODS</b>The deletion rates of mitochondrial DNA (mtDNA) in peripheral blood nucleate cells of 47 exposed workers and 47 non-exposed workers (as control), as well as 12 old people and 12 young people were measured with polymerase chain reaction (PCR).</p><p><b>RESULTS</b>The positive rates of mtDNA deletion in peripheral blood nucleate cells were 17.02% in the workers exposed to ACN and 25.00% in group of old people. However, the mtDNA deletion was not detected in the control group and young people.</p><p><b>CONCLUSIONS</b>ACN could induce mtDNA deletion in peripheral blood nucleate cells of the exposed workers. There may be a potential molecular effect of occupational ACN exposure on workers' aging.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Cells
/
Acrylonitrile
/
DNA Damage
/
Aging
/
DNA, Mitochondrial
/
Occupational Exposure
/
Toxicity
Limits:
Adolescent
/
Aged
/
Aged80
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2003
Type:
Article
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