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Effects of lead exposure on nitric oxide synthase activity in different brain regions of developmental rat / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 263-265, 2003.
Article in Chinese | WPRIM | ID: wpr-265106
ABSTRACT
<p><b>OBJECTIVE</b>To observe the influence of lead exposure on the activity of nitric oxide synthase (NOS) in different brain regions of rat.</p><p><b>METHODS</b>By establishing a series of rat models exposed to different low levels of lead (drinking water containing 0.025%, 0.050%, 0.075% of lead acetate) during developing period, NOS activities in hippocampus, cerebellum, cerebral cortex and brain stem were studied.</p><p><b>RESULTS</b>On the 21st day after birth, NOS activities in hippocampus of three levels of lead exposed groups [(1.53 +/- 0.20), (1.66 +/- 0.23), (1.88 +/- 0.32) U/mg pro respectively], and in cerebellum [(0.87 +/- 0.24), (0.85 +/- 0.09), (0.91 +/- 0.18) U/mg pro respectively] were significantly lower than those of control group [(2.36 +/- 0.18), (1.41 +/- 0.18) U/mg pro, respectively, P < 0.01]. NOS activities in cerebral cortex of 0.075% group [at 7, 14, 21 d of age [(1.29 +/- 0.14), (1.03 +/- 0.15), (0.69 +/- 0.10) U/mg pro] were significantly lower than those in control group [(2.54 +/- 0.31), (1.64 +/- 0.22), (1.24 +/- 0.14) U/mg pro respectively], and 0.025% group [(2.42 +/- 0.19), (1.59 +/- 0.17), (1.27 +/- 0.12) U/mg pro respectively], and 0.050% group [(2.56 +/- 0.53), (1.77 +/- 0.19), (1.24 +/- 0.10) U/mg pro respectively, P < 0.05]. There were no significant differences among control, 0.025%, and 0.050% groups (P > 0.05). Lead exposure had no influence on NOS activity in brain stem at the same age (P > 0.05).</p><p><b>CONCLUSION</b>NOS activities in hippocampus, cerebellum and cerebral cortex were inhibited by low level lead exposure and the degree of the effect was related to Pb exposure time and/or level of Pb exposed.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Brain / Brain Stem / Cerebellum / Cerebral Cortex / Rats, Sprague-Dawley / Nitric Oxide Synthase / Dose-Response Relationship, Drug / Toxicity / Hippocampus Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Brain / Brain Stem / Cerebellum / Cerebral Cortex / Rats, Sprague-Dawley / Nitric Oxide Synthase / Dose-Response Relationship, Drug / Toxicity / Hippocampus Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2003 Type: Article