The effect of overtraining on human sperm chromatin structure / 中华劳动卫生职业病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To identify the effects of overtraining on human sperm DNA.</p><p><b>METHODS</b>Molecular epidemiological investigation of 249 men from different groups (training and non-training) was carried out by using flow cytometer to detect the integrity and damage of in situ DNA of sperm nucleus, and sperm chromatin structure assay was performed.</p><p><b>RESULTS</b>The average COMPalpha(t) in training group was 11.02% while that in control group was 5.90% (P < 0.01). COMPalpha(t) was significantly correlated with sperm activity (r = 0.41, P < 0.05).</p><p><b>CONCLUSION</b>Overtraining could induce sperm DNA injury and affect sperm activity, thus to decrease the potentiality of reproduction.</p>