Evaluation of nasal absorption for geniposide solution / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 839-842, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-265358
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the regulation of geniposide nasal absorption.</p><p><b>METHOD</b>We used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied.</p><p><b>RESULT</b>Geniposide was stable in rats nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL x min(-1), the absorption rate of geniposide remains constant in a dose-independent manner.</p><p><b>CONCLUSION</b>The mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20 x 10(-3).</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Solutions
/
Administration, Intranasal
/
Drugs, Chinese Herbal
/
Kinetics
/
Linear Models
/
Nose
/
Sensitivity and Specificity
/
Iridoids
/
Diffusion
Type of study:
Diagnostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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