Experimental research on cardiotonic effect of active compound from raw and processing aconite roots / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the cardiotonic effect of active compoud from raw and processing aconite roots used rats with acute heart failure (AHF) as the experimental animals.</p><p><b>METHOD</b>Isolated toad cordis was employed to observe the cardiotonic effect and the AHF models were reproduced in rats by pentobarbital sodium to observe the hemodynamics marker acute heart failure, and elucidate cardiotonic effect.</p><p><b>RESULT</b>The DDA(s) and MDA-P improved contractile force obviously on isolated toad cordis (P < 0.05). And the most amplification of contractile force was 91.107% +/- 87.663% (P < 0.01). But the effect on isolated heart rates was not significant. The change of LVSP, +/- dp/dt(max), LVEDP were significant (P < 0.01, P < 0.001), and the HR increased evidently by adminstrate processing aconite roots active compounds after the agent in 5 min.</p><p><b>CONCLUSION</b>There are cardiotonic effect on isolated toad cordis in rats with active compounds from raw and processing aconite roots.</p>